It looks like Wolfram Research has release a huge new release of Mathematica. I have only dabbled in Mathematica but I could spend all day playing and learning with it. It's hard to believe Mathematica came out almost twenty years ago!
Something they've added recently - and apparently improved on - is server based computing and visualization. Imagine what could be done by putting this together with something like Amazon's Elastic Compute Cloud (EC2).
See the Wolfram Blog for more details.